Commonly used chemo drugs for Bone Cancer
According to Cancer.org these are the drugs primarily used to treat bone cancer. They are also used to treat many other types of cancer.
​

• Doxorubicin (Adriamycin®)

• Cisplatin

• Etoposide (VP-16)

• Ifosfamide (Ifex®)

• Cyclophosphamide (Cytoxan®)

• Methotrexate

• Vincristine (Oncovin®)

​
NOTE:

• Did you know that chemo CAUSES CANCER? 

• Did you know that chemo CAUSES DEATH?

• Did you know that chemo CAUSES DEADLY Tumor Lysis Syndrome?

• Did you know that chemo DESTROYS your bone marrow? (This is CRITICAL for life!)

• Did you know that chemo DESTROYS your immune system? (This is also CRITICAL.)

• Did you know that you can experience HEART FAILURE (even years later)?

• Did you know that you can experience KIDNEY FAILURE?

• How do you cure cancer with an agent that causes CANCER and DEADLY TUMORS and CAUSES DEATH?

(NOTE: Doctors will not tell you, but all chemo agents raise the chance for other cancers. This is because it is so toxic it destroys the immune system. Orthodox medicine will not tell you that it is the immune system that heals you... not chemo.)

(NOTE: ALL cells are made in the bone marrow... Red (transport oxygen), White (fight infection), Platelets (help the blood clot), Macrophages (destroys pathogens including cancer and regulates/controls the immune system), etc. Once the bone marrow has been destroyed your life is not long for this world.)


​​Doxorubicin Brand Name: Adriamycin

Warning:
• "The risk of a very bad bone marrow problem and second CANCER (type of leukemia) may be raised after treatment with doxorubicin (conventional). Talk with the doctor." 

• "This medicine may cause severe heart problems like heart failure. This can happen during treatment or years after your last dose. Sometimes, these problems will not go away or may be deadly. The chance may be higher if you have ever had heart problems or chest area radiation, or are using other drugs that may cause heart problems. The chance may be higher if you have ever had doxorubicin (conventional) or other drugs like this one. Ask your doctor (?) if you are not sure if any of your drugs may cause heart problems. The chance of heart problems depends on the dose of this drug and your health problem. In children, the chance of heart problems later in life is higher. Heart problems may happen even without any risk factors. Call your doctor right away if you have cough, fast or slow heartbeat, abnormal heartbeat, swelling in the arms or legs, shortness of breath, sudden weight gain, or feel very tired or weak."

• "You will need to have heart function tests while taking doxorubicin (conventional). Talk with the doctor."

• "This medicine may lower the ability of your bone marrow to make blood cells that your body needs. This can lead to needing a blood transfusion and very bad and sometimes deadly bleeding problems or infections. Tell your doctor right away if you have signs of infection like fever, chills, or sore throat; any bruising or bleeding; or if you feel very tired or weak." 

• "This medicine may cause tissue damage if the drug leaks from the vein. Tell your nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body."

Material Safety Data Sheet

​Warning! Suspect cancer hazard. may cause CANCER. 
Possible risk of impaired fertility. Possible risk of harm to the unborn child.

Target Organs: Blood, kidneys, heart, respiratory system, eyes, bone marrow, immune system, skin, nerves.
Can produce delayed pulmonary edema.

Epidemiology: No epidemiological study of Adriamycin alone was available for review. However, in one study of cancer patients receiving Adriamycin in combination with alkylating agents and radiotherapy, the patients developed leukemia and bone cancer.

California Prop 65
WARNING: This product contains Adriamycin, a chemical known to the state of California to CAUSE CANCER.
WARNING: This product contains Adriamycin, a chemical known to the state of California to cause male REPRODUCTIVE TOXICITY.


Cisplatin

Warning:
• "This medicine may cause kidney problems like KIDNEY FAILURE. You will need to make sure you are not dehydrated before, during, and after doses of Cisplatin. Drink lots of non caffeine liquids and have your blood work checked as you have been told by your doctor."

• "This medicine may cause NERVE PROBLEMS. These nerve problems can get worse the more times you get cisplatin. Sometimes, these nerve problems have not gone back to normal. If you have questions, talk with the doctor." 

• "This medicine may lower the ability of the BONE MARROW to make blood cells that the body NEEDS. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. Some infections have been severe and even DEADLY. If you have questions, talk with the doctor." 

Safety Data Sheet

• GHS Signal Word: Danger

• H350: may cause CANCER. 

NOTE: Category "1" is the most toxic level - Category "2" is not as toxic and so on.

• Acute Toxicity: Oral, Category 2

• Serious Eye Damage/Eye Irritation, Category 1

• Carcinogenicity, Category 1B 

Chronic Toxicological Effects: Cisplatin - Investigated as a drug, mutagen, natural product, reproductive effector, and tumorigen (tumor forming). 

Another MSDS

• EU Indication of danger: MUTAGENIC: Category 2 (damages your DNA and is passed onto offspring)

• Carcinogenic: Category 2

• EU Risk Phrases: R45 - may cause CANCER.

• EU Safety Phrases: R46 - May cause HERITABLE GENETIC DAMAGE.  

​

Etoposide (VP-16)  

Warning:
• "This medicine may lower the ability of your bone marrow to make blood cells that your body needs. This can lead to needing a blood transfusion and very bad and sometimes deadly bleeding problems or infections. Tell your doctor right away if you have signs of infection like fever, chills, or sore throat; any bruising or bleeding; or if you feel very tired or weak." 

Material Safety Data Sheet
 

• GHS Signal Word: Danger

• Carcinogenicity, Category 1B  (highly likely to CAUSE CANCER) 

 

• H302: Harmful if swallowed.

• H350: may cause CANCER.

Everything below is from the Medical-Dictionary

• RENAL (kidney) impairment

Adverse reactions

• CNS: drowsiness, fatigue, headache, vertigo, peripheral neuropathy

• CV: hypotension (with I.V. use), HEART FAILURE, myocardial infarction

• GI: nausea, vomiting, stomatitis

• GU: STERILITY

• Hematologic: anemia, leukopenia, thrombocytopenia, BONE MARROW DEPRESSION

• Hepatic: HEPATOTOXICITY

• Metabolic: hyperuricemia

• Respiratory: PULMONARY EDEMA, bronchospasm

• Other: alopecia, fever, phlebitis at I.V. site, allergic reactions including ANAPHYLAXIS

Methotrexate 

Warning:
For all uses of this medicine:

• "This medicine may raise your chance of lymphoma and other CANCERS."

• "Patients with cancer may be at greater risk of getting a bad and sometimes DEADLY health problem called tumor lysis syndrome (TLS). Talk with the doctor."

• ​"Very bad side effects like BONE MARROW problems, LIVER problems, LUNG problems, INFECTIONS, and skin reactions (Stevens-Johnson syndrome/toxic epidermal necrolysis) can happen with methotrexate injection. Some side effects may not go away and can be DEADLY. You must talk with the doctor about the risks of methotrexate injection." 

• "This medicine may cause KIDNEY PROBLEMS in some patients. Talk with the doctor."

• "Regular blood work and other exams will need to be done to check for side effects. Follow what the doctor has told you."

• "Very bad and sometimes deadly BONE MARROW PROBLEMS and stomach or bowel problems have happened when methotrexate injection was taken with NSAIDs like ibuprofen or naproxen. Talk with the doctor."

• "Tell your doctor if you get diarrhea or mouth or tongue sores or irritation. You may need to stop methotrexate injection. Severe and sometimes deadly bowel problems may happen."

• "Talk with your doctor if you are getting radiation. There may be more chance of harm to tissue and bone."

• "This medicine may cause HARM to an UNBORN BABY or LOSS of an unborn baby. A pregnancy test will be done before you start methotrexate injection to show that you are NOT pregnant."

• "Women must use birth control while taking methotrexate injection and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away."

• "Men with a partner who may get pregnant must use birth control while taking methotrexate injection and for some time after the last dose. Ask your doctor how long to use birth control. If your partner gets pregnant, call the doctor right away."

For all reasons other than cancer treatment:

• "Do not take if you are pregnant."

• "This medicine must only be used when other drugs cannot be used or have not worked. Talk with your doctor to be sure that the benefits of methotrexate injection are more than the risks."

MSDS

Signal Word: Danger

NOTE: Category "1" is the most toxic - Category "2" is not as toxic and so on.

• Germ Cell Mutagenicity Category 1B (damages your DNA and passed onto offspring)

• Reproductive Toxicity Category 1B

• Acute oral toxicity Category 3

• Skin Corrosion/irritation Category 2

• Serious Eye Damage/Eye Irritation Category 2A

• Specific target organ toxicity (single exposure) Category 3

• Target Organs - Respiratory system.

• Specific target organ toxicity - (repeated exposure) Category 2

• Target Organs - Liver, Kidney, Blood.

Hazard Statements

• May cause genetic defects

• May damage fertility.

• May damage the unborn child

• Causes skin irritation Causes serious eye irritation

• May cause respiratory irritation

• Toxic if swallowed

Mutagenic Effects - Mutagenic effects have occurred in humans.(damages your DNA and passed onto offspring)
Reproductive Effects - Adverse reproductive effects have occurred in humans.
Teratogenicity - Teratogenic effects (birth defects) have occurred in humans.

All information below is from the Medical Dictionary

FDA Box Warning:

• "DEATHS have occurred when drug was used to treat cancer and psoriasis."

• Monitor patient closely for BONE MARROW, LIVER, LUNG, and KIDNEY toxicities. Explain risks involved, and stress importance of adequate follow up.

• "Use caution when giving high-dose regimen for osteosarcoma. (High-dose regimens for other cancers are investigational.)"

• "Don't give to pregnant women or women with childbearing potential unless medical evidence suggests benefits may outweigh risks. Drug has caused fetal death and congenital anomalies."

• "Drug elimination is reduced in patients with renal impairment, ascites, or pleural effusions. Monitor them carefully for toxicity; dosage may need to be reduced or drug may need to be stopped."

• "Unexpectedly severe (sometimes FATAL) BONE MARROW SUPPRESSION (all cells are generated in the bone marrow. What would you do without new cells?) and GI toxicity have occurred in patients receiving drug (usually in high doses) concurrently with nonsteroidal anti-inflammatory drugs (NSAIDs)."

• "Drug causes hepatotoxicity, fibrosis, and cirrhosis, but generally only after prolonged use. Acute liver enzyme elevations are common but usually transient and asymptomatic. Perform periodic liver biopsies in psoriasis patients receiving long-term therapy."

• "Potentially DANGEROUS LUNG DISEASE may arise acutely at any time during therapy. Not always fully reversible, it has occurred at dosages as low as 7.5 mg/week."

• "Interrupt therapy for diarrhea and ulcerative stomatitis; otherwise, hemorrhagic enteritis and DEATH from intestinal perforation may occur."

• "MALIGNANT LYMPHOMAS may occur at low dosages and may not require cytotoxic treatment. Discontinue drug first; if lymphoma doesn't regress, begin appropriate treatment." 

•" Drug may induce tumor lysis syndrome in patients with rapidly growing tumors.

• Potentially FATAL opportunistic INFECTIONS may occur.

• When given concomitantly with radiation therapy, drug may increase risk of soft-tissue necrosis and osteonecrosis.


Vincristine (one brand name is Oncovin®) 

Signal Word: Danger

Hazard Statements:

• Toxic if swallowed

• Suspected of causing GENETIC DEFECTS.

• Suspected of damaging FERTILITY.

• Suspected of DAMAGING the UNBORN child.

WARNING. Reproductive Harm - https://www.p65warnings.ca.gov/

pH:  3.5-4.5  (1,000 to 10,000 times more acidic than a normal cell. the perfect environment to grow cancer.)


Everything from here down is from the Medical Dictionary...

Adverse Reactions:

• ​CNS: agitation, insomnia, depression, mental status changes, ascending peripheral neuropathy, transient cortical blindness, seizures, coma

• EENT: diplopia

• GI: nausea, vomiting, constipation, abdominal cramps, stomatitis, anorexia, paralytic ileus

• GU: nocturia, urinary retention, gonadal suppression, oliguria

• Hematologic: anemia, leukopenia, thrombocytopenia (mild and brief)

• Metabolic: hyperuricemia, syndrome of inappropriate antidiuretic hormone secretion

• Respiratory: bronchospasm

• Skin: alopecia

• Other: tissue necrosis (with extravasation), phlebitis at I.V. site

These next two chemo agents are found on this page.


Ifosfamide (Ifex®) 

To learn more about this chemo agent please click here.


Cyclophosphamide (Cytoxan®) 

To learn more about this chemo agent please click here.